Enaksha R. Wickremsinhe: search on Z-Library

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1

A decade of incurred sample reanalysis: failures, investigations and impact

Lee, Lisa B, Wickremsinhe, Enaksha R

Journal:

Year:

2018

Language:

english

File:

PDF, 180 KB

english, 2018

2

Microsampling: considerations for its use in pharmaceutical drug discovery and development

Spooner, Neil, Anderson, Kenneth D, Siple, Joe, Wickremsinhe, Enaksha R, Xu, Yang, Lee, Mike

Journal:

Year:

2019

Language:

english

File:

PDF, 420 KB

english, 2019

3

Validation of 96-well equilibrium dialysis with non-radiolabeled drug for definitive measurement of protein binding and application to clinical development of highly-bound drugs

Maciej J. Zamek-Gliszczynski, Kenneth J. Ruterbories, Rose T. Ajamie, Enaksha R. Wickremsinhe, Lavanya Pothuri, Mukkavilli V. S. Rao, Vinay N. Basavanakatti, Jakir Pinjari, Vikram K. Ramanathan, Ajai

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 121 KB

english, 2011

4

Validating regulatory-compliant wide dynamic range bioanalytical assays using chip-based nanoelectrospray tandem mass spectrometry

Enaksha R. Wickremsinhe, Bradley L. Ackermann, Ajai K. Chaudhary

Journal:

Rapid Communications in Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 207 KB

english, 2005

5

High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC–MS/MS

Wickremsinhe, Enaksha R., Lee, Lisa B., Schmalz, Chris A., Torchia, John, Ruterbories, Kenneth J.

Journal:

Journal of Chromatography B

Year:

2013

Language:

english

File:

PDF, 660 KB

english, 2013

6

Fully-Automated Approach for Online Dried Blood Spot Extraction and Bioanalysis by Two-Dimensional-Liquid Chromatography Coupled with High-Resolution Quadrupole Time-of-Flight Mass Spectrometry

Oliveira, Regina V., Henion, Jack, Wickremsinhe, Enaksha

Journal:

Analytical Chemistry

Year:

2014

Language:

english

File:

PDF, 1.56 MB

english, 2014

7

Phase 1 dose escalation and pharmacokinetic evaluation of oral gemcitabine prodrug (LY2334737) in combination with docetaxel in patients with advanced solid tumors

Salazar, Ramon, Morales, Serafin, Gil-Martín, Marta, Aguirre, Elena, Oaknin, Ana, Garcia, Margarita, Callies, Sophie, Wickremsinhe, Enaksha R., Benhadji, Karim A., Llombart, Antonio

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2014

Language:

english

File:

PDF, 397 KB

english, 2014

8

Quantification of Gemcitabine Incorporation into Human DNA by LC/MS/MS as a Surrogate Measure for Target Engagement

Wickremsinhe, Enaksha R., Lutzke, Barry S., Jones, Barry R., Schultz, Gary A., Freeman, Angela B., Pratt, Susan E., Bones, Angela M., Ackermann, Bradley L.

Journal:

Analytical Chemistry

Year:

2010

Language:

english

File:

PDF, 638 KB

english, 2010

9

Automated high-capacity on-line extraction and bioanalysis of dried blood spot samples using liquid chromatography/high-resolution accurate mass spectrometry

Oliveira, Regina V., Henion, Jack, Wickremsinhe, Enaksha R.

Journal:

Rapid Communications in Mass Spectrometry

Year:

2014

Language:

english

File:

PDF, 962 KB

english, 2014

10

Dried blood spot sampling: coupling bioanalytical feasibility, blood–plasma partitioning and transferability to in vivo preclinical studies

Wickremsinhe, Enaksha R, Abdul, Basira G, Huang, Naijia H, Richard, John W, Hanes, Jennifer L, Ruterbories, Kenneth J, Perkins, Everett J, Chaudhary, Ajai K

Journal:

Year:

2011

Language:

english

File:

PDF, 774 KB

english, 2011

11

Automated direct extraction and analysis of dried blood spots employing on-line SPE high-resolution accurate mass bioanalysis

Oliveira, Regina V, Henion, Jack, Wickremsinhe, Enaksha R

Journal:

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

12

Implementing Dried Blood Spot Sampling for Clinical Pharmacokinetic Determinations: Considerations from the IQ Consortium Microsampling Working Group

Evans, Christopher, Arnold, Mark, Bryan, Peter, Duggan, Jeffrey, James, Christopher A, Li, Wenkui, Lowes, Steve, Matassa, Luca, Olah, Timothy, Timmerman, Philip, Wang, Xiaomin, Wickremsinhe, Enaksha,

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 418 KB

english, 2015

13

Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors

Wickremsinhe, Enaksha R., Hynes, Scott M., Palmieri, Margo D., Mitchell, Malcolm I., Abraham, Trent L., Rehmel, Jessica Fayer, Chana, Emilie, Jost, Lorenz M., Cassidy, Kenneth C.

Journal:

Year:

2014

Language:

english

File:

PDF, 946 KB

english, 2014

14

Dried blood spot analysis for rat and dog studies: validation, hematocrit, toxicokinetics and incurred sample reanalysis

Wickremsinhe, Enaksha

Journal:

Year:

2015

Language:

english

File:

PDF, 1.06 MB

english, 2015

15

A Review of Nanoelectrospray Ionization Applications for Drug Metabolism and Pharmacokinetics

Wickremsinhe, Enaksha R., Singh, Gurkeerat, Ackermann, Bradley L., Gillespie, Todd A., Chaudhary, Ajai K.

Journal:

Current Drug Metabolism

Year:

2006

Language:

english

File:

PDF, 587 KB

english, 2006

16

Preclinical bridging studies: understanding dried blood spot and plasma exposure profiles

Wickremsinhe, Enaksha R, Huang, Naijia H, Abdul, Basira G, Knotts, Kirk, Ruterbories, Kenneth J, Manro, Jason R

Journal:

Year:

2013

Language:

english

File:

PDF, 1.14 MB

english, 2013

17

Phase I dose escalation and pharmacokinetic evaluation of two different schedules of LY2334737, an oral gemcitabine prodrug, in patients with advanced solid tumors

Faivre, Sandrine J., Olszanski, Anthony J., Weigang-Köhler, Karin, Riess, Hanno, Cohen, Roger B., Wang, Xuejing, Myrand, Scott P., Wickremsinhe, Enaksha R., Horn, Candice L., Ouyang, Haojun, Callies,

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 790 KB

english, 2015

18

Evaluation of the likelihood of a selective CHK1 inhibitor (LY2603618) to inhibit CYP2D6 with desipramine as a probe substrate in cancer patients

Hynes, Scott M., Wickremsinhe, Enaksha, Zhang, Wei, Decker, Rodney, Ott, Jennifer, Chandler, Jason, Mitchell, Malcolm

Journal:

Biopharmaceutics & Drug Disposition

Year:

2015

Language:

english

File:

PDF, 346 KB

english, 2015

19

Phase I Study of CHK1 Inhibitor LY2603618 in Combination with Gemcitabine in Patients with Solid Tumors

Calvo, Emiliano, Braiteh, Fadi, Von Hoff, Daniel, McWilliams, Robert, Becerra, Carlos, Galsky, Matthew D., Jameson, Gayle, Lin, Ji, McKane, Scott, Wickremsinhe, Enaksha R., Hynes, Scott M., Bence Lin,

Journal:

Year:

2016

Language:

english

File:

PDF, 527 KB

english, 2016

20

Incorporating dried blood spot LC–MS/MS analysis for clinical development of a novel oncolytic agent

Wickremsinhe, Enaksha R, Callies, Sophie, Schmalz, Chris A, Lee, Lisa B, LaBell, Elizabeth S, Satonin, Darlene K

Journal:

Year:

2018

Language:

english

File:

PDF, 4.30 MB

english, 2018

21

A First-in-Human Phase 1 Study of LY3023414, an Oral PI3K/mTOR Dual Inhibitor, in Patients with Advanced Cancer

Bendell, Johanna C., Varghese, Anna M., Hyman, David M., Bauer, Todd M., Pant, Shubham, Callies, Sophie, Lin, Ji, Martinez, Ricardo, Wickremsinhe, Enaksha R., Fink, Aaron, Wacheck, Volker, Moore, Kath

Journal:

Clinical Cancer Research

Year:

2018

Language:

english

File:

PDF, 1.74 MB

english, 2018

22

Preclinical Absorption, Distribution, Metabolism, and Excretion of an Oral Amide Prodrug of Gemcitabine Designed to Deliver Prolonged Systemic Exposure

Wickremsinhe, Enaksha, Bao, Jingqi, Smith, Richard, Burton, Richard, Dow, Shannon, Perkins, Everett

Journal:

Year:

2013

Language:

english

File:

PDF, 353 KB

english, 2013

23

Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse

Patel, Nita J, Wickremsinhe, Enaksha, Hui, Yu-Hua, Barr, Alexandar, Masterson, Nicholas, Ruterbories, Kenneth, Weller, Jennifer, Hanes, Jennifer, Kern, Tom, Perkins, Everett

Journal:

Journal of Pharmacy and Pharmaceutical Sciences

Year:

2016

Language:

english

File:

PDF, 1.41 MB

english, 2016

24

Microsampling for quantitative bioanalysis, an industry update: output from an AAPS/EBF survey

Patel, Shefali R, Bryan, Peter, Spooner, Neil, Timmerman, Philip, Wickremsinhe, Enaksha

Journal:

Year:

2019

Language:

english

File:

PDF, 314 KB

english, 2019

25

Disposition of [ 14 C]LY2606368 following intravenous administration in patients with advanced and/or metastatic solid tumours

Wickremsinhe, Enaksha R., Hynes, Scott M., Payne, Christopher D., Guo, Yingying, Cassidy, Kenneth C.

Journal:

Year:

2019

File:

PDF, 1.37 MB

2019

26

Evaluation of correlation between bioanalytical methods

Gleason, Carol R, Ji, Qin C, Wickremsinhe, Enaksha R

Journal:

Year:

2020

File:

PDF, 377 KB

2020

27

Land OâLakes Workshop on Microsampling: Enabling Broader Adoption

Wickremsinhe, Enaksha R, Ji, Qin C., Gleason, Carol R., Anderson, Melanie, Booth, Brian P.

Journal:

The AAPS Journal

Year:

2020

File:

PDF, 242 KB

2020

28

Patient-centric sampling special focus issue

Spooner, Neil, Anderson, Melanie, Wickremsinhe, Enaksha R

Journal:

Year:

2020

File:

PDF, 154 KB

2020